PAPSS2 polyclonal antibody
产品名称： PAPSS2 polyclonal antibody
英文名称： PAPSS2 polyclonal antibody
产品编号： PAB3306
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PAPSS2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PAPSS2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.
Xu ZH, Otterness DM, Freimuth RR, Carlini EJ, Wood TC, Mitchell S, Moon E, Kim UJ, Xu JP, Siciliano MJ, Weinshilboum RM.Biochem Biophys Res Commun. 2000 Feb 16;268(2):437-44.
- 2.
- Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2.
Kurima K, Singh B, Schwartz NB.J Biol Chem. 1999 Nov 19;274(47):33306-12.
- 3.
- Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse.
Faiyaz ul Haque M, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH.Nat Genet. 1998 Oct;20(2):157-62.
- Applications
- Western Blot (Cell lysate)
- The PAPSS2 polyclonal antibody (Cat # PAB3306) is used in Western blot to detect PAPSS2 in Jurkat cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with PAPSS2 polyclonal antibody (Cat # PAB3306) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 9060
- Protein Accession#:
- NP_001015880
- Gene Name:
- PAPSS2
- Gene Alias:
- ATPSK2,SK2
- Gene Description:
- 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Omim ID:
- 603005
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2,ATP sulfurylase/APS kinase 2,ATP sulfurylase/adenosine 5'-phosphosulfate kinase,PAPS synthase 2,PAPS synthetase 2,bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2,phosphoadenosine-