PTGS2 polyclonal antibody
产品名称: PTGS2 polyclonal antibody
英文名称: PTGS2 polyclonal antibody
产品编号: PAB12301
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PTGS2.
- Immunogen:
- A synthetic peptide corresponding to amino acids at N-terminus of human PTGS2.
- Sequence:
- NRGVCMSVGFDQYKCDCTRTGFY
- Host:
- Rabbit
- Theoretical MW (kDa):
- 68.9
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- Different to the related rat sequence by two amino acids.
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation.
Brewer JA, Khor B, Vogt SK, Muglia LM, Fujiwara H, Haegele KE, Sleckman BP, Muglia LJ.Nat Med. 2003 Oct;9(10):1318-22. Epub 2003 Aug 31.
- 2.
- COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity.
Wilkinson-Berka JL, Alousis NS, Kelly DJ, Gilbert RE.Invest Ophthalmol Vis Sci. 2003 Mar;44(3):974-9.
- 3.
- Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice.
Liu CH, Chang SH, Narko K, Trifan OC, Wu MT, Smith E, Haudenschild C, Lane TF, Hla T.J Biol Chem. 2001 May 25;276(21):18563-9. Epub 2001 Mar 7.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Entrez GeneID:
- 5743
- Gene Name:
- PTGS2
- Gene Alias:
- COX-2,COX2,GRIPGHS,PGG/HS,PGHS-2,PHS-2,hCox-2
- Gene Description:
- prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
- Omim ID:
- 600262
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq
- Other Designations:
- OTTHUMP00000033524,cyclooxygenase 2b,prostaglandin G/H synthase and cyclooxygenase,prostaglandin-endoperoxide synthase 2
- Related Disease
- Acute Disease
- Acute-Phase Reaction
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