PTPN2 monoclonal antibody, clone T25-AF3B7
产品名称： PTPN2 monoclonal antibody, clone T25-AF3B7
英文名称： PTPN2 monoclonal antibody, clone T25-AF3B7
产品编号： MAB2739
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant PTPN2.
- Immunogen:
- Recombinant protein corresponding to human PTPN2.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease.
Doody KM, Bourdeau A, Tremblay ML.Immunol Rev. 2009 Mar;228(1):325-41.
- 2.
- TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}.
Bourdeau A, Dube N, Heinonen KM, Theberge JF, Doody KM, Tremblay ML.Blood. 2007 May 15;109(10):4220-8. Epub 2007 Jan 18.
- 3.
- Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
Galic S, Klingler-Hoffmann M, Fodero-Tavoletti MT, Puryer MA, Meng TC, Tonks NK, Tiganis T.Mol Cell Biol. 2003 Mar;23(6):2096-108.
- Applications
- Western Blot (Transfected lysate)
- Immunoblot analysis of cell lysates.
Lane 1 : Bosc23 cell lysate.
Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau (1-441 a. a.).
Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPN2 (1-387E a. a.).
Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1.
- Entrez GeneID:
- 5771
- Gene Name:
- PTPN2
- Gene Alias:
- PTPT,TC-PTP,TCELLPTP,TCPTP
- Gene Description:
- protein tyrosine phosphatase, non-receptor type 2
- Omim ID:
- 176887
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq
- Other Designations:
- T-cell protein tyrosine phosphatase
- Related Disease
- Addison Disease
- Arthritis
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Carcinoma
- Celiac Disease
- Colitis, Ulcerative
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Progression
- Disease Susceptibility
- Genetic Predisposition to Disease
- Ileal Diseases
- Inflammatory Bowel Diseases
- Lupus Erythematosus, Systemic
- Prostatic Neoplasms