EPHB2 (C-term) Peptide
产品名称： EPHB2 (C-term) Peptide
英文名称： EPHB2 (C-term) Peptide
产品编号： P2634
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of EPHB2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human EPHB2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Oligomeric structure of the human EphB2 receptor SAM domain.
Thanos CD, Goodwill KE, Bowie JU.Science. 1999 Feb 5;283(5403):833-6.
- 2.
- A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals.
Tang XX, Pleasure DE, Brodeur GM, Ikegaki N.Oncogene. 1998 Jul 30;17(4):521-6.
- 3.
- cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.
Fox GM, Holst PL, Chute HT, Lindberg RA, Janssen AM, Basu R, Welcher AA.Oncogene. 1995 Mar 2;10(5):897-905.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of EPHB2 polyclonal antibody (Cat # PAB3020) in NCI-H460 cell lysate. EPHB2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma reacted with EPHB2 polyclonal antibody (Cat # PAB3020), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 2048
- Protein Accession#:
- P29323
- Gene Name:
- EPHB2
- Gene Alias:
- CAPB,DRT,EPHT3,ERK,Hek5,MGC87492,PCBC,Tyro5
- Gene Description:
- EPH receptor B2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq
- Other Designations:
- OTTHUMP00000002914,OTTHUMP00000002916,developmentally-regulated eph-related tyrosine kinase,elk-related tyrosine kinase,eph tyrosine kinase 3,ephrin receptor EphB2,prostate cancer-brain cancer susceptibility
- Gene Pathway
- Related Disease
- Adenomatous Polyposis Coli
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Intestinal Polyposis
- Parkinson Disease
- Parkinson disease
- Precancerous Conditions
- Prostate cancer
- Prostatic Neoplasms