METAP2 (N-term) Peptide
产品名称： METAP2 (N-term) Peptide
英文名称： METAP2 (N-term) Peptide
产品编号： P1066
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of METAP2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human METAP2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese.
Wang J, Sheppard GS, Lou P, Kawai M, Park C, Egan DA, Schneider A, Bouska J, Lesniewski R, Henkin J.Biochemistry. 2003 May 6;42(17):5035-42.
- 2.
- Negative regulation of the protection of eIF2alpha phosphorylation activity by a unique acidic domain present at the N-terminus of p67.
Datta R, Tammali R, Datta B.Exp Cell Res. 2003 Feb 15;283(2):237-46.
- 3.
- Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.
Endo H, Takenaga K, Kanno T, Satoh H, Mori S.J Biol Chem. 2002 Jul 19;277(29):26396-402. Epub 2002 May 6.
- Entrez GeneID:
- 10988
- Protein Accession#:
- AMP2_HUMAN
- Gene Name:
- METAP2
- Gene Alias:
- MAP2,MNPEP,p67,p67eIF2
- Gene Description:
- methionyl aminopeptidase 2
- Omim ID:
- 601870
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq
- Other Designations:
- eIF-2-associated p67 homolog,initiation factor 2-associated 67 kDa glycoprotein,peptidase M 2
- Related Disease