IL17A (Human) Recombinant Protein
产品名称: IL17A (Human) Recombinant Protein
英文名称: IL17A (Human) Recombinant Protein
产品编号: P3631
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Human IL17A (Q16552, 20 a.a. - 134 a.a.) partial recombinant protein expressed in Escherichia coli.
- Sequence:
- IPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
- Theoretical MW (kDa):
- 16
- Form:
- Lyophilized
- Preparation Method:
- Escherichia coli expression system
- Purification:
- Ion exchange column and HPLC reverse phase column
- Purity:
- > 95% by SDS-PAGE and HPLC
- Endotoxin Level:
- < 0.1 ng/ug (1 EU/ug)
- Activity:
- The ED50 was determined by the dose-dependent proliferation of induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/mL., corresponding to a specific activity of <5 x 105 units/mg.
- Storage Buffer:
- Lyophilized from PBS, pH 7.5
- Storage Instruction:
- Store at -20°C on dry atmosphere for 2 years.
After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.
Aliquot to avoid repeated freezing and thawing.
- Application Image
- Functional Study
- SDS-PAGE
- Entrez GeneID:
- 3605
- Protein Accession#:
- Q16552
- Gene Name:
- IL17A
- Gene Alias:
- CTLA8,IL-17,IL-17A,IL17
- Gene Description:
- interleukin 17A
- Omim ID:
- 603149
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq
- Other Designations:
- OTTHUMP00000016597,cytotoxic T-lymphocyte-associated antigen 8,cytotoxic T-lymphocyte-associated protein 8,cytotoxic T-lymphocyte-associated serine esterase 8,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- Gene Pathway
- Related Disease
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Breast Neoplasms
- Bronchiolitis
- Bronchiolitis, Viral
- Colitis, Ulcerative
- Disease Progression
- Dyspepsia
- Genetic Predisposition to Disease
- Helicobacter Infections
- Infant, Premature, Diseases
- Inflammation
- Multiple Sclerosis
- Respiratory Syncytial Virus Infections
- Stomach Neoplasms
- Tobacco Use Disorder